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	Provedor de dados Anais da ABC (AABC) (2) BJMBR (1) BJM (1) Genet. Mol. Biol. (1) J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Azizi,Maryam (1) Barbosa,João A.R.G. (1) Bustos-Valenzuela,J.C. (1) Farah,Chuck S. (1) Granjeiro,J.M. (1) Hemmat,Jafar (1) Higa,Roberto Hiroshi (1) Karimi,Soodabeh (1) Meneghini,Rogério (1) Moraes,Adolfo Henrique (1) Mulloy,Barbara (1) Netto,Luis E.S. (1) Oliveira,R.C. (1) Schenkman,Sergio (1) Seifati,Seyed Morteza (1) Sogayar,M.C. (1) Taga,R. (1) Torktaz,Ibrahim (1) Tozzi,Clésio Luis (1) Valente,Ana Paula (1) Mais... Palavra-chave Protein structure (6) Bone morphogenetic proteins (1) Carboxymethyl cellulase (1) Clinical trial (1) Dermatan sulfate (1) Development (1) Endoglucanase (1) Fucans (1) Growth factors (1) Heparan sulfate (1) Heparin (1) Hot spots (1) Hot spots prediction (1) Meta-analysis (1) Nuclear magnetic resonance (1) Nuclear magnetic resonance spectroscopy (1) Osteogenic protein (1) Protein crystallography (1) Protein-antibody interaction (1) Protein-small compound interaction (1) Mais... Tipo do documento Info:eu-repo/semantics/article (6) Ano 2019 (1) 2015 (1) 2009 (1) 2006 (1) 2005 (2) País Brazil (6) Idioma Inglês (6)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 6 Primeira ... 1 ... Última Bone morphogenetic proteins: from structure to clinical use BJMBR Granjeiro,J.M.; Oliveira,R.C.; Bustos-Valenzuela,J.C.; Sogayar,M.C.; Taga,R.. Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming growth factor ß superfamily. Family members are expressed during limb development, endochondral ossification, early fracture, and cartilage repair. The activity of BMPs was first identified in the 1960s but the proteins responsible for bone induction were unknown until the purification and cloning of human BMPs in the 1980s. To date, about 15 BMP family members have been identified and characterized. The signal triggered by BMPs is transduced through serine/threonine kinase receptors, type I and II subtypes. Three type I receptors have been shown to bind BMP ligands, namely: type IA and IB BMP receptors and type IA activin receptors. BMPs seem to be... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bone morphogenetic proteins; Osteogenic protein; Protein structure; Meta-analysis; Clinical trial. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001000003 Characterization of a thermostable endoglucanase produced by Isoptericola variabilis sp. IDAH9 BJM Azizi,Maryam; Hemmat,Jafar; Seifati,Seyed Morteza; Torktaz,Ibrahim; Karimi,Soodabeh. Abstract This study aimed to isolate and evaluate the cellulase activity of cellulolytic bacteria in hot springs of Dehloran, Ilam province, Iran. Water and sludge samples were collected from the hot springs and the bacterial enrichment was performed in a medium containing rice barn and carboxymethyl cellulose (CMC). The cultures were incubated at 50 °C in aerobic conditions. The bacteria were isolated on CMC agar (1%) medium. Cellulase assay of the isolates was measured by the evaluation of endoglucanase enzyme activity, which is also called as carboxymethyl cellulase (CMCase). The isolated thermotolerant bacteria were then identified and optimized for the production of CMCase. Moreover, stabilizing elements of the enzyme were identified with in silico... Tipo: Info:eu-repo/semantics/article Palavras-chave: Carboxymethyl cellulase; Endoglucanase; Thermophiles; Protein structure. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000401225 Prediction of binding hot spot residues by using structural and evolutionary parameters Genet. Mol. Biol. Higa,Roberto Hiroshi; Tozzi,Clésio Luis. In this work, we present a method for predicting hot spot residues by using a set of structural and evolutionary parameters. Unlike previous studies, we use a set of parameters which do not depend on the structure of the protein in complex, so that the predictor can also be used when the interface region is unknown. Despite the fact that no information concerning proteins in complex is used for prediction, the application of the method to a compiled dataset described in the literature achieved a performance of 60.4%, as measured by F-Measure, corresponding to a recall of 78.1% and a precision of 49.5%. This result is higher than those reported by previous studies using the same data set. Tipo: Info:eu-repo/semantics/article Palavras-chave: Hot spots prediction; Protein structure; Hot spots. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000300029 The specificity of interactions between proteins and sulfated polysaccharides Anais da ABC (AABC) Mulloy,Barbara. Sulfated polysaccharides are capable of binding with proteins at several levels of specificity. As highly acidic macromolecules, they can bind non-specifically to any basic patch on a protein surface at low ionic strength, and such interactions are not likely to be physiologically significant. On the other hand, several systems have been identified in which very specific substructures of sulfated polysaccharides confer high affinity for particular proteins; the best-known example of this is the pentasaccharide in heparin with high affinity for antithrombin, but other examples may be taken from the study of marine invertebrates: the importance of the fine structure of dermatan sulfate (DS) to its interaction with heparin cofactor II (HCII), and the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sulfated polysaccharides; Fucans; Dermatan sulfate; Heparan sulfate; Heparin; Protein structure; Growth factors; Development. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000400007 The structural molecular biology network of the State of São Paulo, Brazil Anais da ABC (AABC) Barbosa,João A.R.G.; Netto,Luis E.S.; Farah,Chuck S.; Schenkman,Sergio; Meneghini,Rogério. This article describes the achievements of the Structural Molecular Biology Network (SMolBNet), a collaborative program of structural molecular biology, centered in the State of São Paulo, Brazil, and supported by São Paulo State Funding Agency (FAPESP). It gathers twenty scientific groups and is coordinated by the scientific staff of the Center of Structural Molecular Biology, at the National Laboratory of Synchrotron Light (LNLS), in Campinas. The SMolBNet program has been aimed at 1) solving the structure of proteins of interest related to the research projects of the groups. In some cases, the choice has been to select proteins of unknown function or of possible novel structure obtained from the sequenced genomes of the FAPESP genomic program; 2)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Structural genomics; Protein crystallography; Nuclear magnetic resonance; Protein structure. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000200006 Zika virus proteins at an atomic scale: how does structural biology help us to understand and develop vaccines and drugs against Zika virus infection? J. Venom. Anim. Toxins incl. Trop. Dis. Valente,Ana Paula; Moraes,Adolfo Henrique. Abstract In Brazil and in other tropical areas Zika virus infection was directly associated with clinical complications as microcephaly in newborn children whose mothers were infected during pregnancy and the Guillain-Barré syndrome in adults. Recently, research has been focused on developing new vaccines and drug candidates against Zika virus infection since none of those are available. In order to contribute to vaccine and drug development efforts, it becomes important the understanding of the molecular basis of the Zika virus recognition, infection and blockade. To this purpose, it is essential the structural determination of the Zika virus proteins. The genome sequencing of the Zika virus identified ten proteins, being three structural (protein E,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Zika virus proteins; Structural biology; Protein structure; Nuclear magnetic resonance spectroscopy; Protein-antibody interaction; Protein-small compound interaction. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100206 Registros recuperados: 6 Primeira ... 1 ... Última

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